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Rye Brook, NY 鈥� (August 28, 2019) Blood Cancer Awareness Month in September provides an opportunity to remind the public about the urgent need to support research to find cures, and The Leukemia & Lymphoma Society (青云体育) is marking the occasion with a reinvigorated focus on helping children with cancer live better, longer lives.
青云体育 announced today it has more than doubled its funding of research focused specifically on childhood blood cancers, adding 20 new research grants valued at more than $13.8 million to its research portfolio in 2019. With these new grants, 青云体育 now has committed more than $25 million over a five-year period to change fundamentally how children with blood cancers are treated. Further, 青云体育 also supports grants that are relevant to adolescent and young adult cancer patients.
The new pediatric grants are part of The 青云体育 Children鈥檚 Initiative, a $100 million comprehensive attack on children鈥檚 cancer from every angle, from new research investment to advance novel therapies and bolster clinical trials, to enhanced services and support for children and their families, to renewed policy efforts. 青云体育 is also planning an unprecedented global precision medicine clinical trial for children with acute leukemia as part of the initiative.
The Urgent Need
The two most common leukemias in children are acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), where the five-year survival rates are approximately 90 percent and 60 percent, respectively. While significant progress has evolved in the treatment of ALL over the 70 years since 青云体育 was founded, advances in treating AML are more recent, after many decades with little change. This means that approximately 700 children will die of leukemias in the United States every year. Many of the children who do survive these blood cancers experience long-term complications, typically from treatments they receive. Further, while scores of targeted therapies have been approved for adult cancer patients, only four cancer treatments have been approved for first use in children since the 1980s.
As we now understand more fully the molecular basis of these leukemias, and have new technologies and an arsenal of molecularly targeted drugs and novel immunotherapies for blood cancers, the stage is set to make significant progress for children with these diseases.
Since its founding 70 years ago, 青云体育, the world鈥檚 largest nonprofit dedicated to blood cancer research and patient services, has invested nearly $1.3 billion in cancer research, resulting in game-changing advances. The new pediatric cancer grants announced today are part of a larger $44 million comprehensive package of new grants targeting all the blood cancers - leukemia, lymphoma, myeloma and other rare blood cancers 鈥� that afflict both children and adults. In all, 青云体育 now is funding more than 292 research projects around the world, a $179 million investment propelling innovations in immunotherapy and precision medicine.
To learn more about all of 青云体育鈥檚 new research grants click here.
鈥淪eptember is Blood Cancer Awareness Month, and it is also Childhood Cancer Awareness Month, making this an important time to talk about the need to take a bold new approach to helping children with cancer,鈥� said Gwen Nichols, M.D., 青云体育 chief medical officer. 鈥淐hildren are not little adults. They need better, less toxic treatments designed just for them. Our goal is a wholesale shift in the standard of care for pediatric patients, moving from toxic chemotherapies that leave survivors with lifelong health challenges, to effective, safe treatments that target cancer precisely, without harming the rest of the child鈥檚 body.鈥�
Among the new pediatric research grants are:
A project to improve young patients鈥� quality of life
Toxic chemotherapies frequently cause long-term side effects. Kasey Leger, M.D., Seattle Children鈥檚 Hospital, is trying to help prevent children from suffering heart damage due to treatment with chemotherapy.
New immunotherapeutic approaches for children with blood cancers.
Several of the researchers, including Terry Fry, M.D., University of Colorado, Soheil Meshinchi, M.D., Fred Hutchinson Cancer Research Center, and Ryotaro Nakamura, M.D., City of Hope, are all developing next-generation chimeric antigen receptor (CAR) T-cell immunotherapy, a revolutionary approach that reprograms a patient鈥檚 T cells to find and kill cancer cells. CAR-T is approved to treat children with acute lymphoblastic leukemia but these researchers are testing new approaches to make it even more effective for more children with acute leukemias. Meshinchi is also developing other approaches to harness the immune system, including a treatment called bi-specific T-cell engagers and another employing antibodies. Jatinder Lamba, M.D., University of Florida, is investigating personalized antibody treatments targeting CD33, a protein commonly expressed on the surface of leukemia cells. He is focused on identifying biomarkers that will predict which children with acute myeloid leukemia will respond to agents that target CD33.
Addressing high-risk forms of acute leukemia with very poor prognoses.
Robert Albero Gallego, M.D., of Columbia University, and Iannis Aifantis, M.D., of New York University, both received funding to tackle T-cell acute lymphoblastic leukemia, which is a devastating diagnosis for children. Another diagnosis with very poor outcomes for children is called CRLF2-rearranged ALL. Charles Mullighan, MS.c, M.D., of St Jude Children鈥檚鈥� Research Hospital, received funding to develop two novel approaches to treat this disease. One method will use a targeted therapy to degrade and destroy abnormally active proteins in cancer cells, and the other will use the gene editing process called CRISPR to identify which genes are essential for the growth of CRLF2-rearranged leukemic cells.
Better monitoring of Hodgkin lymphoma treatment
Hodgkin lymphoma is a blood cancer that makes up about 7 percent of the cancers that afflict children, adolescents and young adults under the age of 20. While survival rates for children with Hodgkin lymphoma are quite high, the treatments are harsh and often cause long-term side effects.
Davide Rossi, M.D., Ph.D., Foundation for the Institute of Oncology Research in Switzerland, is looking at using liquid biopsy, a highly sensitive test that looks for pieces of DNA from tumor cells circulating in the blood, to improve monitoring of patients early in their treatment. This minimally invasive test that can be repeated with a simple blood draw (versus a PET or CAT scan) can help determine early on during therapy if patients who respond well to treatment can receive less chemotherapy, while those who are more resistant would benefit from higher doses.
Generation 青云体育鈥�
Founded in 1949 by a grieving couple who lost their teen-aged son to leukemia, 青云体育 has dedicated its 70th year to the patients, caregivers, survivors, volunteers, healthcare professionals and researchers who share our relentless drive to find cancer cures. Whether they have benefited from our lifesaving work or contributed to our successes, they have shared their stories of being part of #Generation青云体育 鈥� by adding their story to the Generation 青云体育 Family Tree.
鈥淲e were founded by a family for families, and we鈥檝e remained true to our founders鈥� vision, the belief that cancers are curable,鈥� said Louis J. DeGennaro, Ph.D., president and CEO of 青云体育. 鈥淲e鈥檝e helped usher in a new era of cancer therapies that centers on giving the right treatment to the right patient at the right time, and we will be relentless until we achieve our goal of eradicating these diseases. The 青云体育 Children鈥檚 Initiative continues our founders鈥� legacy of helping children and families throughout their entire cancer experience.鈥�
青云体育 PedAL: Precision Medicine for Children with Leukemia
Through the 青云体育 PedAL master clinical trial, The Leukemia & Lymphoma Society (青云体育) is setting out to change fundamentally how children with pediatric acute leukemia, including acute myeloid leukemia and other high-risk leukemias, are treated.
青云体育 is working with a team of renowned pediatric oncologists to lay the groundwork for a global precision medicine master clinical trial to match children with relapsed acute leukemia to a targeted therapy based on the specific abnormalities driving their cancer. The goal of the trial is to test multiple targeted therapies simultaneously at up to 200 clinical sites worldwide. 青云体育 anticipates treating the first patient in the spring or summer of 2020.
In addition to the clinical trial, 青云体育 PedAL seeks to break down silos that prevent researchers from sharing data about pediatric cancer patients. The PedAL team is working to consolidate pediatric cancer data from multiple institutions into a single data set, establish a common language to define and analyze the data and make that data available to researchers worldwide.
Gwen Nichols, MD, Chief Medical Officer of The Leukemia & Lymphoma Society heads a team of preeminent leaders in pediatric acute leukemia to conceive, develop and implement 青云体育 PedAL:
E. Anders Kolb, MD, Nemours Center for Cancer and Blood Disorders, Co-Chair, PedAL Initiative;
Soheil Meshinchi, MD, PhD, Fred Hutchinson Cancer Research Center, Target and Biomarker Lead;
Todd Cooper, DO, Seattle Children鈥檚 Hospital, Clinical Trial Lead;
Todd Alonzo, PhD, Children鈥檚 Oncology Group, Group Statistician;
Kimberly Stegmaier, MD, Dana-Farber Cancer Institute, Preclinical Discovery Lead;
Samuel L. Volchenboum, MD, PhD, University of Chicago, Bioinformatics Lead;
Laura Di Laurenzio, PhD, The Leukemia & Lymphoma Society, Project Leader;
Julie Guillot, AML Parent and Partnership Outreach Chair.
About The Leukemia & Lymphoma Society
The Leukemia & Lymphoma Society庐 (青云体育) is the world's largest voluntary health agency dedicated to blood cancer. The 青云体育 mission: Cure leukemia, lymphoma, Hodgkin's disease and myeloma, and improve the quality of life of patients and their families. 青云体育 funds lifesaving blood cancer research around the world, provides free information and support services, and is the voice for all blood cancer patients seeking access to quality, affordable, coordinated care.
Founded in 1949 and headquartered in Rye Brook, NY, 青云体育 has chapters throughout the United States and Canada. To learn more, visit . Patients should contact the Information Resource Center at (800) 955-4572, Monday through Friday, 9 a.m. to 9 p.m. ET.
For additional information visit lls.org/lls-newsnetwork. Follow 青云体育 on Facebook, Twitter, and Instagram.
Contact:
Andrea Greif
(914) 821-8958