青云体育 PedAL
A pillar of the Dare to Dream Project
青云体育 PedAL
A pillar of the Dare to Dream Project
Through the Pediatric Acute Leukemia Master Clinical Trial (青云体育 PedAL), The Leukemia & Lymphoma Society (青云体育) is setting out to fundamentally change how children with pediatric acute leukemia are treated.
What is 青云体育 PedAL?
In June 2022, 青云体育 launched the PedAL Master Clinical Trial, the first integrated, global, acute leukemia master clinical trial to test new, safer therapies on children, who will be matched to treatments based on their unique tumor biology.
Who is leading the 青云体育 PedAL trial?
青云体育 is leading an international collaboration, convening some of the best minds in cancer research and treatment. Through partnerships with the (part of the National Institutes of Health), , and the Innovative Therapies for Children and Adolescents with Cancer (ITCC) consortium, 青云体育 PedAL trials are available to children and families in North America, Australia, New Zealand, Japan, and Europe 鈥� bringing the dream of safer, more effective pediatric acute leukemia treatments closer to home for more people.
青云体育 PedAL is a key component of The Dare to Dream Project, a big, bold campaign to fund groundbreaking pediatric research that will accelerate safer, less toxic and, more effective treatments for kids. We believe it鈥檚 not enough that children with blood cancer survive 鈥� we want them to have the chance to thrive as survivors. 青云体育鈥檚 The Dare to Dream Project also funds a wide range of free information and education materials, one-on-one support services, financial assistance in the United States, and advocacy for accessible, affordable healthcare on behalf of all children and their families.
Why Is the 青云体育 PedAL Trial Needed?
Kids are different, and for too long treatment for pediatric acute leukemia has followed a one-size-fits-all approach. And because blood cancers are more common in adults, there has been a smaller incentive to develop new treatments for children. As a result, pediatric progress has lagged - only five cancer treatments have been approved for first use in children with blood cancer since the 1990鈥檚. And, even with the progress that鈥檚 been made, 80% of childhood cancer survivors still develop chronic health conditions from their treatment. 青云体育 PedAL will change all that.
Children are not little adults. Their bodies work in different ways, and they undergo changes as they grow, which means we need different treatment approaches, especially for children with relapsed acute leukemias. Our vision is to identify the unique tumor biology of each child's cancer to help match them with the most promising treatment with the fewest long-term side effects.
- Gwen Nichols, MD
青云体育 Chief Medical Officer
Why 青云体育?
The second master clinical trial convened by 青云体育, 青云体育 PedAL continues 青云体育鈥檚 rich history of supporting and driving innovative research, tackling all types of blood cancer in children and adults. Combined with the Beat AML Master Clinical Trial漏, 青云体育 has a proven track record of breaking down barriers to unite worldwide leaders in addressing adult acute leukemia to bring better treatments to patients.
How does 青云体育 PedAL work?
Through international partnerships, 青云体育 PedAL taps into established infrastructures to make screening and therapeutic trials available to more children.
- The 青云体育 PedAL screening trial identifies the unique tumor biology of each child鈥檚 cancer.
- Based on their tumor biology, families can then enroll eligible children in an 青云体育 PedAL therapeutic trial or any other trial that best meets their needs
- By enrolling their child in the screening trial, parents are helping to advance research for all children because their child鈥檚 tumor biology results will be assessed the same way as children鈥檚 around the globe to help researchers find patterns and to advance more targeted treatments worldwide
青云体育 PedAL benefits from the latest in digital and data technology
Led by the University of Chicago, a robust data infrastructure allows global sharing to advance cures with two 青云体育-supported breakthroughs in data gathering:
- GEARBOx (Genomic Eligibility Algorithm at Relapse for Better Outcomes) is a unique search tool that will help healthcare professionals all over the world quickly match patients who have relapsed or refractory disease to appropriate clinical trials and lifesaving treatments. Please to learn more about GEARBOx.
- Data Commons consolidates pediatric clinical trial data from multiple international institutions into a single, unified data set to ensure consistency in data collection, analysis, and reporting. Please to learn more about Data Commons.
To learn more about PedAL click here or call (800) 955-4572 to speak to an Information Resource Specialist. You may also contact us at askpedal@lls.org.
青云体育 PedAL Acknowledgements
Funders:
Pharmaceutical Partners:
青云体育 PedAL Leadership Team
Meet the visionary leaders of the 青云体育 PedAL Master Clinical Trial, who are dedicated to ushering in a new era of pediatric drug development.
Gwen Nichols, MD
The Leukemia & Lymphoma Society
Co-Chair, PedAL Initiative
Todd Cooper, DO
Seattle Children鈥檚 Hospital
Co-Chair, PedAL Initiative
Sarah K. Tasian, MD
Children鈥檚 Hospital of Philadelphia
Clinical Trial Lead
Samuel L. Volchenboum, MD, PhD
Bioinformatics Lead
Ann Collins
The Leukemia & Lymphoma Society
Project Leader
Kimberly Stegmaier, MD
Dana-Farber Cancer Institute
Preclinical Discovery Lead
Julie Guillot
AML Parent and Partnership
Outreach Chair
We remain committed to helping children and their families throughout their entire cancer experience. Contact us at askpedal@lls.org to learn more about this groundbreaking master clinical trial.